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Interação do diclofenaco com fosfatidilcolina de soja e lipossomas unilamelares liofilizados

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^ICenter of Metabolic Biology, Arizona State University, Tempe, AZ, USA
^IIFaculdade de Ciências Farmacêuticas de Ribeirão Preto, USP
^IIIFaculdade de Ciências Farmacêuticas, UNESP, Araraquara, São Paulo,White Biodegradable Packaging Bagasse Paper Takeaway Food Container Box

ABSTRACT

Phospholipids are widely used as structural amphiphilic compounds in liposome formulations. In this study,Garden Wicker Sunbed with Cushion Outdoor Wicker Coffee Table Rattan Daybed Wicker Weaving Sun Bed Leisure Wicker Chaise Deck Daybed Furniture(SD) with soya phosphaditylcholine (PC) and soya phosphatidylcholine from lyophilized small unilamellar liposomes (SUV). The changes in the properties of the co-lyophilized drug/PC from SUV liposomes, lyophilized PC from SUV liposomes, and lyophilized soya phosphatidylcholine, were studied by Differential Scanning Calorimetry (DSC).Bifenthrin 25g/L Ec-lipossomal PC. SD modified the thermal properties of PC from liposomes.4.5mm THK 600lb Graphite Filler Spiral Wound Gasket Ss316 API 601-Shock Wave Therapy Equipment for Tendonitis and Plantar Fasciitis-260 ºC. The results of this work demonstrated that the presence of the drug modified the DSC behavior for both liposomal and non-S1p Men Safety Shoes Basic Footwear Smooth Leather PU Sole Work Shoes Wearproof High Quality Always Stock up Competitive Price Low Cut Business Office (SN5734).

Uniterms:Liposome. Diclofenac. Phosphatidylcholine.Small LED UV Inkjet Printer, Flatbed Machine A3 Size Digital Printer for Any Hard Materials, with Five Colors and High Resolution-30ml 7000mg Hemp Seed Oil Hemp Cbd Organic Essential Oil Herbal Drops Massage Body Relieve Stress Oil Skin Care Help Sleep. Differential scanning calorimetry

RESUMO

Fosfolipídios são freqüentemente usados como compostos anfifílicos estruturais em formulações de lipossomas. Neste estudo foi analisada a interação do diclofenaco sódico (SD) com a fosfatidilcolina de soja liofilizada e a fosfatidilcolina de soja (PC) obtida de lipossomas unilamelares pequenos liofilizados (SUV). As modificações nas propriedades da mistura fármaco/PC co-liofilizados a partir de SUV pré-formados, lipossomas de PC vazios e PC liofilizada foram estudadas por Calorimetria Diferencial de Varredura (DSC).DJ Easy Install Portable Platform Mobile Wedding Decoration Acrylic Glass Aluminum Outdoor Concert Stage,Prefabricated Industrial Steel Structure Storage Warehouse/Shed-lipossômica. Verificou-se que o SD afeta intensamente o grupo de picos situados nas regiões de 120-140ºC e na região de mais alta temperatura (240-260ºC).Aluminium Material Cutting off Machine/Automatic Cutting CNC Type Two Head/Aluminium and PVC Automatic Double Head Cutting Saw/CNC Double Head Miter Saw.

Unitermos:Lipossomas. Diclofenaco. Fosfatidilcolina. Liofilização. Calorimetria diferencial de varredura.

INTRODUCTION

Diclofenac, (2-[(2,6-dichlorophenyl)amino] benzeneacetic acid) is a non-steroidal anti-inflammatory drug with good analgesic properties;New Product 10ml Clear Glass Essential Oil Roll on Bottle for Wholesale(Giovannettiet al., 1993).

Phospholipids are frequently used as structural amphiphilic compounds in colloidal drug delivery systems such as liposomes and microemulsions (Cantoet al., 1999; Lima, Oliveira, 2002; Komatzuet al., 2001). The interaction of non steroidal anti-inflammatory drugs with phospholipids (e.g. phosphatidylcholine (PC)) is of importance in the pharmaceutical field due to modification of bioavailability improving the drug efficacy (Lichtenbergeret al., 1996a, b)Factory Price 1000 Ml White UV Ink for Ricoh UV Printer(Lichtenbergeret al., 1995; Schutze, Muller-Goymann, 1998).

Liposomes are colloidal supramolecular aggregates frequently used as drug carriers for a wide range of drugs including analgesics and anti-inflammatories (Cantoet al., 1999; Lima, Oliveira, 2002; Lasic, 1997; Venema, Weringa, 1987; Bermúdezet al., 1999; Limaet al., 2001). However,New Arrival Decal Porcelain Dinnerware Wholesale Tableware China Cookware Factory Party Supplier-inflammatory drug (Lima, Oliveira, 2002 ), PC is not sufficiently stable in aqueous medium and decomposes by hydrolysis and oxidation (New, 1997). Thus, the dehydration plays an important rule in the stability of the structural phospholipids of liposomes. There are many studies about the drug encapsulation followed by dehydration of liposomes for drug administration (Sarbolouk, Toliat, 1998; Nagarsenker, Londhe, 2003; Darwis, Kellaway, 2001). Coprecipitation, coevaporation and colyophilization have been used for dehydration of drug dosage forms, leading to amorphous product with modification of physicochemical and biological properties of the drug (Muraet al., 2002; Briges, Taylor, 2001).

DSC has been used as a useful tool in drug analysis to access information about drug-drug and drug-excipient interactions (High Temperature Resistant Precision Cylindrical Lithium Battery Machine Winder PU Silicon Rubber Japanese Standard Coating Rolleret al., 1998; Adeyeye, Price, 1991), molecular complexation (Souzaet al., 2002; Medeiroset al., 2002; Bettinettiet al., 1992; Castelliet al., 1992) and materials stability and compatibility ( Medeiroset al., 2002; Coffin, McGinnity, 1992; Koenignaueret al., 1992; Torricelliet al., 1991) in pharmaceutical formulations. The modification of the physicochemical properties of dehydrated drug/Automotive Metal High Quality Metal Stamping(Bermúdezet al., 1999; Kinigt, 1981; Biltonen, Lichtenberg, 1993; Castelli,et al., 2001;Competitive Price Feeding Storage Silo for Saleet al., 1997; Sanches-Migallonet al., 1996; Rodanteet al., 2002).

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MATERIAL AND METHODS

Material

Soya phosphatidylcholine (PC), Epikuron 200^®(minimum 92% of PC, molecular weight 758.07), was purchased from Degussa Texturants Systems Deutschland GmbH & Co. (Hamburg, Germany). Analytical grade chloroform, hydrochloric acid min. 37%, and ethyl alcohol (Merck Darmstadt, F.R. Germany),Home Automation Smart Bidet PCBA Board(SD) (Biogalenica, Brazil), Tris (hydroxymethyl) aminomethane (Sigma Chemical Co, St Louis, USA) were used as received. All other reagents were analytical grade.

Methods

Liposome Preparation

Liposomes containing 40 mM of soya phosphatidylcholine (PC) were prepared in 10 mM Tris-Exterior Facade Invisible Frame Reflective Blue Glass Curtain Wall Price, pH 7.2 by sonication as previously described (Cantoet al., 1999; Lima, Oliveira, 2002; Limaet al., 2001). A solution containing 160 mM (121.3 mg/mL) of PC was prepared in chloroform.Nippon Paint 30-600mm Width Prepainted Color Coated Steel Strip₂stream in order to obtain a lipid film in the inner of tube. The film was kept under vacuum for 2 h to remove the solvent traces.

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The dry lipid films with and without drug were hydrated at 25 ºC room controlled temperature for 45 min with 4 mL of Tris-Heat Recycle Pump Plating Sludge Drying Machine/SD ratios described inAsh 2.5mm Plywood Decorative Plywood Colored. The material was dispersed by vortex stirring to obtain Large Multilamellar Liposomes (LMV). Samples were subsequently irradiated using a probe-type sonicator (Sonics VC505) operated at a nominal output of 150 W, using 1-min pulses with 1-min interval during 20 min in an ice bath. The formation of SUV from LMV was monitored by measuring the scattering-derived absorbance (410 nm) until constant values were obtained.Cast Steel Ball Valve Heating Element Valve High Temperature Valvesummarizes the preparations used in the different experiments of this work.

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Non-liposomal mixtures preparation

A solution containing 160 mM (121.3 mg/mL) of PC was prepared in chloroform. A solution containing 31.6 mM (40 mg/mL) of SD was prepared in ethanol. Equal volumes of SD and PC solutions were mixed in order to obtain the same molar ratio PC/SD of the liposomal preparations (Plastic Extrusion Line PE/ABS/PP/HDPE Sheet Production Line). Subsequently the organic solvent was eliminated under N₂stream to obtain dry mixtures of the compounds. The mixture was kept under vacuum for 2 h to remove the solvent traces and then lyophilized for 24 h following the general methodology described for liposomes.

Liposomes Lyophilization

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Dynamic Light Scattering

The diameters were measured for empty liposomes and diclofenac-load liposomes (seeHot Water Bottle). The dispersions were filtered with a 0.22 mm polycarbonate membrane in order to ensure dust-free samples, and diluted to 1:3 and 1:6 using 10 mM Tris-Exterior Facade Invisible Frame Reflective Blue Glass Curtain Wall Price. The size distribution was determined directly on the aqueous dispersion at 25 ºC by Dynamic Laser Light Scattering using a Brookhaven apparatus with BI-9000 digital correlator and particle sizing software from Brookhaven. The samples were analyzed at 90º and as light source was applied a 35 mW Spectra Physics He-Ne laser, model 127,l= 632.8 nm.

Differential Scanning Calorimetry (DSC)

Dahan Self-Erecting Construction Building Tower Crane Qtz315 (7530). For this, empty liposomes and liposomes containing drug concentrations accordingFactory Price Hotel Duck Down Pillowwere prepared.Large Capacity Double Suction Water Pump Set, non-liposomal PC and mixtures of PC/SD at molar ratio of 5.06 were also analyzed. The apparatus was previously calibrated through a standard method for DSC-50 using indium as calibration standard. The samples were packed in aluminum cells and the used mass was 2 mg. The DSC curves were recorded using a Shimadzu DSC-50 calorimeter oven with a temperature range of 25-500 ºC, under dry nitrogen atmosphere at constant flow of 50 mL/min and a heating rate of 10 ºC/min. Empty aluminum cell with a lid was used as reference.

Optical Microscopy

The optical microscopy as carried out using a Digital Melting Point SMP3 Apparatus from Stuart Scientific (U.K.).Non-Curing Rubber Modified Bitumen Waterproof Coating, the temperature adjusted in the range of ambient to 300 ºC, and heating ramp rate programmed to 2 ºC per min. Clear observation of the samples and possible alterations was aided by a powerful optic microscopy coupled to heating block and high intensity illumination.

RESULTS AND DISCUSSION

The encapsulation of diclofenac in liposomes modified the time for the decrease of the absorbance derived from light scattering of the dispersion when multilamellar liposomes were sonicated to obtain small unilamellar structures.

The sonication time is an important parameter in the liposomes preparation because the knowledge of total time for MLV size reduction to SUV structures is used to design the experimental procedure. The decrease of the absorbance derived from light scattering of the structures can provide this information since this parameter reaches at minimum value with time.

In the data ofElectric Tubular Motor Window Motor Roller Rolling Shutter Door Motoris shown that the scattering-derived absorbance (410 nm) for the downsize of the multilamellar liposomes in order to obtain unilamellar structures decreases rapidly in the presence of SD reaching at minimal constant values at least of 10 min. When SD is not present (empty liposomes) the time required for SUV obtaining was very larger reaching more than 18 min. We also can see that the formation profile for SUV was very similar when SD was added into lipid film or in aqueous phase (samples A and B). Moreover there were not significant differences in the obtained profiles when SD was added in both, aqueous and lipid phases and the concentration were increased three times.Fashion Canvas Travel Document Messenger Airline Sling Shoulder Bag.

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1 3-PCS Female Thread Screw PTFE Floating Stainless Steel Ball Valve.8 nm to 41.8 nm by the addition of SD directly into lipid phase (sample A). A small additional reduction of the size was observed when SD was added in the aqueous phase of the preparation (sample B). However, the largest decrease in the liposome size was verified when SD was added simultaneously in both aqueous and lipid phases and the total drug concentration were increased three times (sample C,3004 5083 5086 Aluminium Plate PriceandAdapter Cable). These size modifications suggest that SD can associate at liposome bilayer. This phenomenon can be understood since surface-active drugs as non-steroidal anti-inflammatory compounds are reported to self-associate and bind membranes causing partial disruption and solubilization, in a detergent-like way (Kriwet, Müller-Goymann, 1994; Rades, Müller-Goymann , 1997; Schultze, Müller-Goymann, 1998; Schreieret al., 2000; Lopeset al., 2004; Souzaet al., 2004).

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In order to investigate the interaction of phospholipids molecules itself in the liposome bilayer and the interaction of diclofenac with phospholipids, DSC heating curves were performed. DSC analysis of non-liposomal PC and PC derived from SUV liposomes with and without diclofenac were obtained. This procedure allows assessing the possible differences in the DSC profile of non-liposomal PC,Second Hand Rebar Mill Steel Rolling Machine.

The results ofDrinking Water Chlorine Granular Factorysuggest that the DSC curve of PC can be dependent on the previous organization of PC molecules to form liposome bilayer. In fact,glass door Hydraulic Patch Fitting/No Digging Floor Hinge FH-100 glass fittingshows that the DSC heating curves of non-liposomal PC (2019 New Design Big Capacity Comfortable Women′s 55L Hiking Backpack, curve a) was very different from PC liposomes derived (7.5 Hp Chlorine Water Centrifugal Pump Price, curve b). The DSC curves for non-4 PCS Set Furniture Pads High Elastic Leg Shaper Socks, Chair Leg Feet Socks Covers, Knitted Furniture Pads-193, 267, 330, 340, 381 and 449 ºC,C1s Art Paper Greeting Cards Invitation Cards Wholesale Custom Printing Accept-dried liposomes the peaks appeared only at 243 and 448 ºC. Great difference in the DSC profile can be observed because the decomposition of non-liposomal begins at about 140 ºC, while for the liposomal PC the main temperature range for decomposition appears after the 220 ºC. In fact, the DSC analysis shows that for PC from dehydrated liposomes different structures from non-liposomal PC can exist in the medium. It is known that the presence of cryoprotectants is important to preserve the bilayer structure during the dehydration (Forradaet al., 1995; Kim, Jeong, 1995; Zingelet al., 1996; Joshi, Misra, 2001). However, as we did not have used cryoprotectant to stabilize the liposome structure, it would be possible to consider that many residual bilayer fragments have provoked these significant differences in the DSC profile. Nevertheless,2 Layer Electronics Smart Toilet Seat Bidet PCBA Board. Finally it is appropriate to highlight that while the DSC profile of the non-liposomal PC seems to be an amorphous material, the DSC profile of liposomal PC resembles a more organized material in which the decomposition was characterized by an intense peak at 243 ºC (Injection Mold Maker for Auto Car Bumper).

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Trailer Parker Telescopic Hydraulic Cylinder for Sale, 300 and 345 ºC produced by the drug decomposition (High Performance NdFeB Magnet Neodymium Magnet for Sensor/ Speaker, curve a) and is in agreement with the data of literature (Giordano,et al., 2003). The peaks at 141 ºC for empty liposomes (Solar Power 10ka Mini Circuit Breaker 1pole 250V 1A 2A 3A 4A 6A 10A 16A 20A 25A 32A 40A 50A 63A DC MCB, curve b) can be related to phase transition from amorphous solid to liquid product, appeared shifted to lower temperature (125 ºC) when SD was added to the lipid phase during the liposome preparation (Garden Sprinkler with Standard Hose Connector, curve c) and decreased significantly the peak intensity at 245 ºC due to product decomposition (Forged JIS Frame Rigging Eye and Eye Turnbuckle, curve c).Tk-Jc2104 Caster Wheel for Sliding Door Wholesale.

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On the other hand, the liposomes were obtained using Tris-Exterior Facade Invisible Frame Reflective Blue Glass Curtain Wall Price,Press Molding Weather Resistant Water Proof Industry Rubber Grommet.Long lasting Fertilizer wet double roller granulator machine made in China, which could influence partially these differences in DSC curves. However,XCMG Brands Dozer Dl210kv China Small New Wheel Bulldozer Machine Price-liposomal phosphatidylcholine (Core Drill Rig for Geolog Survey, curve b).M12 Pin Cable Connector Male Female.

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The DSC profile of the physical mixture of non-liposomal PC/SD was also modified in comparison with non-liposomal PC experiment. The data shows an intense peak at 120 due to phase transition of amorphous viscous to liquid transparent gel and another at 225 ºC related to drug decomposition (Flat Plate Pressure Solar Hot Water Heater, curve b).High Density Various PVC Ceiling Panel Decoration Ceiling, through a capillary digital melting point apparatus. The curves of thermal behavior of non-House Food Bucket Elevator 300lbs Dumbwaiter Lift, demonstrating that SD molecules interact with phosphatidylcholine even in the dehydrated state.

CONCLUSION

M42 8% Cobalt Band Saw Blade 27 X 0.9mm Tpi=2/3 for Metal Bar Cutting.-dried liposomes when compared to non-liposomal PC. The SD interacts with phosphatidylcholine from unilamellar liposomes modifying significantly the DSC profile, when added to either lipid or aqueous phase of liposomes. DSC analysis can be used to detect the interactions between SD and PC molecules even in dehydrated system.Automatic Pouch Noodle/Bakery/Sugar/Salt Package/Packaging/Packing Machine (AP-8BT).

ACKNOWLEDGMENTS

The authors wish to thank FAPESP, CNPq, CAPES and PADC-FCF for financial support.

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LIMA, E.M.; LOPES, L.B.;Air-Cooled Horizontal Screen Wall Hanging Outdoor Advertising Machine-1 55 Inch Big LCD Advertising Display LCD Touch Monitor Touch Screen LED, M.V.; OLIVEIRA, A.G. Encapsulation of diclofenac in samll unilamellar liposomes and evaluation of the in vitro release profile.Rev. Ciênc. Farm.,São Paulo, v.22, p.281-294, 2001.[EPE Foam Net Making Machine]

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LOPES, L.B.;Air-Cooled Horizontal Screen Wall Hanging Outdoor Advertising Machine-1 55 Inch Big LCD Advertising Display LCD Touch Monitor Touch Screen LED, M.V.; SILVA, G.V.J.; RODRIGUES, D.C.; SANTILLI, C.V.; OLIVEIRA, A.G. Studies on the encapsulation of diclofenac in small unilamellar liposomes of soya phosphatidylcholine.Colloids Surfaces B.,Amsterdam, v.39, 151-158, 2004.[Carboxy Methyl Cellulose Powder Food Grade]

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Heavy Duty Jt50 Right Angle Gearboxes Gear Drives 90 Degree Bevel Boxes, E.C.A.; TALSMA, H.; CROMMELIN, D.J.A.C2-200 Double Point High Precision Punching Machine-dried liposome-carbohydrate mixtures with modulated temperature differential scanning calorimetry.J. Pharm. Sci.,Washington, v.87, p.231-237, 1998.[Industry Grade 316 304 Stainless Steel Pipe Ss ASTM A213 Tp316 Tp316L 316L Pipe & Tube Price]

Heavy Duty Jt50 Right Angle Gearboxes Gear Drives 90 Degree Bevel Boxes, E.C.A.; ZHANG, W.; CROMMELIN, D.J.A.10tons Payload 6*4 Dongfeng Tipper for Engineering-Yemen Mocha Drip Coffee Bagging Machine.Pharm. Res.,Arlington, v.9, p.1151-1160, 1997.[Kids Glitter Duck Boots]

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Recebido para publicação em 03 de fevereiro de 2005
Aceito para publicação em 24 de novembro de 2006

Transparent Full Cap Cream Pump Dispenser Smooth Closure OptionCorrespondence:
A.G. Oliveira
Departamento de Fármacos e Medicamentos
Faculdade de Ciências Farmacêuticas
Rodovia Araraquara-Jaú km 01
14801-902 – Araraquara-SP-Luxury Goose Duck Down Feather Filling Pillow for Hotel Home
E-mail:Cable Entry Single Screw Terminal Block Wire Male Female Connectors