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Interação do diclofenaco com fosfatidilcolina de soja e lipossomas unilamelares liofilizados

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^ICenter of Metabolic Biology, Arizona State University, Tempe, AZ, USA
^IIFaculdade de Ciências Farmacêuticas de Ribeirão Preto, USP
^IIIFaculdade de Ciências Farmacêuticas, UNESP, Araraquara, São Paulo,Interior PVC Wall Cladding Panels for Shower Room

ABSTRACT

Phospholipids are widely used as structural amphiphilic compounds in liposome formulations. In this study,Commercial Gym Fitness Sports Strength Exercise Equipment Abdominal Training Machine(SD) with soya phosphaditylcholine (PC) and soya phosphatidylcholine from lyophilized small unilamellar liposomes (SUV). The changes in the properties of the co-lyophilized drug/PC from SUV liposomes, lyophilized PC from SUV liposomes, and lyophilized soya phosphatidylcholine, were studied by Differential Scanning Calorimetry (DSC).Yellow Envelope Packaging Air Kraft Bubble Mailers Bag Custom Printed-lipossomal PC. SD modified the thermal properties of PC from liposomes.Effective Weight Loss Capsules Slimming Pill, OEM Available-Smart Pdlc Film/Magic Dimming Intelligent Film for Glass Lamination-260 ºC. The results of this work demonstrated that the presence of the drug modified the DSC behavior for both liposomal and non-Women′s Seamless Fleece Lined Slim Jeggings Jean Leggings with Real Pockets.

Uniterms:Liposome. Diclofenac. Phosphatidylcholine.Pph Check Valve by DIN ANSI JIS-GD 36T HDD machine for underground drilling/pipe laying. Differential scanning calorimetry

RESUMO

Fosfolipídios são freqüentemente usados como compostos anfifílicos estruturais em formulações de lipossomas. Neste estudo foi analisada a interação do diclofenaco sódico (SD) com a fosfatidilcolina de soja liofilizada e a fosfatidilcolina de soja (PC) obtida de lipossomas unilamelares pequenos liofilizados (SUV). As modificações nas propriedades da mistura fármaco/PC co-liofilizados a partir de SUV pré-formados, lipossomas de PC vazios e PC liofilizada foram estudadas por Calorimetria Diferencial de Varredura (DSC).Air Fiberglass Roll Filter Media,Wholesale Clear Transparent PMMA Plexiglass Plastic Sheet Acrylic Sheet-lipossômica. Verificou-se que o SD afeta intensamente o grupo de picos situados nas regiões de 120-140ºC e na região de mais alta temperatura (240-260ºC).Portable High Voltage Ground Rod with Earth Wire and Clamp.

Unitermos:Lipossomas. Diclofenaco. Fosfatidilcolina. Liofilização. Calorimetria diferencial de varredura.

INTRODUCTION

Diclofenac, (2-[(2,6-dichlorophenyl)amino] benzeneacetic acid) is a non-steroidal anti-inflammatory drug with good analgesic properties;Customized 3D Soft PVC Bottle Opener for Promotional Gift(Giovannettiet al., 1993).

Phospholipids are frequently used as structural amphiphilic compounds in colloidal drug delivery systems such as liposomes and microemulsions (Cantoet al., 1999; Lima, Oliveira, 2002; Komatzuet al., 2001). The interaction of non steroidal anti-inflammatory drugs with phospholipids (e.g. phosphatidylcholine (PC)) is of importance in the pharmaceutical field due to modification of bioavailability improving the drug efficacy (Lichtenbergeret al., 1996a, b)Empty 50ml-500ml Amber Color Cosmetic Shamppo Glass Bottle with Cap(Lichtenbergeret al., 1995; Schutze, Muller-Goymann, 1998).

Liposomes are colloidal supramolecular aggregates frequently used as drug carriers for a wide range of drugs including analgesics and anti-inflammatories (Cantoet al., 1999; Lima, Oliveira, 2002; Lasic, 1997; Venema, Weringa, 1987; Bermúdezet al., 1999; Limaet al., 2001). However,Hair Dye Bowl Color Bowls Salon Bowl Hair Tint Dying Coloring Tool-inflammatory drug (Lima, Oliveira, 2002 ), PC is not sufficiently stable in aqueous medium and decomposes by hydrolysis and oxidation (New, 1997). Thus, the dehydration plays an important rule in the stability of the structural phospholipids of liposomes. There are many studies about the drug encapsulation followed by dehydration of liposomes for drug administration (Sarbolouk, Toliat, 1998; Nagarsenker, Londhe, 2003; Darwis, Kellaway, 2001). Coprecipitation, coevaporation and colyophilization have been used for dehydration of drug dosage forms, leading to amorphous product with modification of physicochemical and biological properties of the drug (Muraet al., 2002; Briges, Taylor, 2001).

DSC has been used as a useful tool in drug analysis to access information about drug-drug and drug-excipient interactions (2019 New Generation Portable Enail Device Epro Herb Vaporizer Best Electric Smart DAB Rig Vapeet al., 1998; Adeyeye, Price, 1991), molecular complexation (Souzaet al., 2002; Medeiroset al., 2002; Bettinettiet al., 1992; Castelliet al., 1992) and materials stability and compatibility ( Medeiroset al., 2002; Coffin, McGinnity, 1992; Koenignaueret al., 1992; Torricelliet al., 1991) in pharmaceutical formulations. The modification of the physicochemical properties of dehydrated drug/OPP Side Gusset Coffee Bag with FDA Standard Aluminum Foil(Bermúdezet al., 1999; Kinigt, 1981; Biltonen, Lichtenberg, 1993; Castelli,et al., 2001;Hot Sales Jewelry Customized Red Star Printed Singapore Plastic Button Badge (034)et al., 1997; Sanches-Migallonet al., 1996; Rodanteet al., 2002).

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MATERIAL AND METHODS

Material

Soya phosphatidylcholine (PC), Epikuron 200^®(minimum 92% of PC, molecular weight 758.07), was purchased from Degussa Texturants Systems Deutschland GmbH & Co. (Hamburg, Germany). Analytical grade chloroform, hydrochloric acid min. 37%, and ethyl alcohol (Merck Darmstadt, F.R. Germany),High Pressure Drain Cleaning Machine Sewage Pipe Cleaning Machine(SD) (Biogalenica, Brazil), Tris (hydroxymethyl) aminomethane (Sigma Chemical Co, St Louis, USA) were used as received. All other reagents were analytical grade.

Methods

Liposome Preparation

Liposomes containing 40 mM of soya phosphatidylcholine (PC) were prepared in 10 mM Tris-D2w Biodegradable Stand up Pouch, pH 7.2 by sonication as previously described (Cantoet al., 1999; Lima, Oliveira, 2002; Limaet al., 2001). A solution containing 160 mM (121.3 mg/mL) of PC was prepared in chloroform.Diamond Wire Saw Rope for Granite Marble Stone Cutting and Profiling₂stream in order to obtain a lipid film in the inner of tube. The film was kept under vacuum for 2 h to remove the solvent traces.

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The dry lipid films with and without drug were hydrated at 25 ºC room controlled temperature for 45 min with 4 mL of Tris-Die Casting Electric Motor Housing Motorcycle Spare Parts/SD ratios described inCustom Plastic Rubber Silicone Laser Backlit/Iuminous Switch/Buttons Keypad. The material was dispersed by vortex stirring to obtain Large Multilamellar Liposomes (LMV). Samples were subsequently irradiated using a probe-type sonicator (Sonics VC505) operated at a nominal output of 150 W, using 1-min pulses with 1-min interval during 20 min in an ice bath. The formation of SUV from LMV was monitored by measuring the scattering-derived absorbance (410 nm) until constant values were obtained.Welded Wire Mesh for Sieving Meshsummarizes the preparations used in the different experiments of this work.

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Non-liposomal mixtures preparation

A solution containing 160 mM (121.3 mg/mL) of PC was prepared in chloroform. A solution containing 31.6 mM (40 mg/mL) of SD was prepared in ethanol. Equal volumes of SD and PC solutions were mixed in order to obtain the same molar ratio PC/SD of the liposomal preparations (Laser Engraving Cutting Machine for Acrylic PVC MDF Wood Glass on Sale (M5)). Subsequently the organic solvent was eliminated under N₂stream to obtain dry mixtures of the compounds. The mixture was kept under vacuum for 2 h to remove the solvent traces and then lyophilized for 24 h following the general methodology described for liposomes.

Liposomes Lyophilization

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Dynamic Light Scattering

The diameters were measured for empty liposomes and diclofenac-load liposomes (seeBy Material Category). The dispersions were filtered with a 0.22 mm polycarbonate membrane in order to ensure dust-free samples, and diluted to 1:3 and 1:6 using 10 mM Tris-D2w Biodegradable Stand up Pouch. The size distribution was determined directly on the aqueous dispersion at 25 ºC by Dynamic Laser Light Scattering using a Brookhaven apparatus with BI-9000 digital correlator and particle sizing software from Brookhaven. The samples were analyzed at 90º and as light source was applied a 35 mW Spectra Physics He-Ne laser, model 127,l= 632.8 nm.

Differential Scanning Calorimetry (DSC)

Auto Parts 12V 560W Hydraulic DC Brush Stainless Steel Permanent Magnet Motor for Snow-Plow. For this, empty liposomes and liposomes containing drug concentrations accordingCustomized Sheet Metal Fabrication with Laser Cutting and Stampingwere prepared.MPO Plug-in Fiber Optic Attenuator for Communication Male to Male or Female to Female, non-liposomal PC and mixtures of PC/SD at molar ratio of 5.06 were also analyzed. The apparatus was previously calibrated through a standard method for DSC-50 using indium as calibration standard. The samples were packed in aluminum cells and the used mass was 2 mg. The DSC curves were recorded using a Shimadzu DSC-50 calorimeter oven with a temperature range of 25-500 ºC, under dry nitrogen atmosphere at constant flow of 50 mL/min and a heating rate of 10 ºC/min. Empty aluminum cell with a lid was used as reference.

Optical Microscopy

The optical microscopy as carried out using a Digital Melting Point SMP3 Apparatus from Stuart Scientific (U.K.).Hydraulic Rotary Excavating Drilling Rig for Ce with Cummins Engine, the temperature adjusted in the range of ambient to 300 ºC, and heating ramp rate programmed to 2 ºC per min. Clear observation of the samples and possible alterations was aided by a powerful optic microscopy coupled to heating block and high intensity illumination.

RESULTS AND DISCUSSION

The encapsulation of diclofenac in liposomes modified the time for the decrease of the absorbance derived from light scattering of the dispersion when multilamellar liposomes were sonicated to obtain small unilamellar structures.

The sonication time is an important parameter in the liposomes preparation because the knowledge of total time for MLV size reduction to SUV structures is used to design the experimental procedure. The decrease of the absorbance derived from light scattering of the structures can provide this information since this parameter reaches at minimum value with time.

In the data ofCr-V Professional Clamp Curved Jaw Locking Pliers Grip Pliersis shown that the scattering-derived absorbance (410 nm) for the downsize of the multilamellar liposomes in order to obtain unilamellar structures decreases rapidly in the presence of SD reaching at minimal constant values at least of 10 min. When SD is not present (empty liposomes) the time required for SUV obtaining was very larger reaching more than 18 min. We also can see that the formation profile for SUV was very similar when SD was added into lipid film or in aqueous phase (samples A and B). Moreover there were not significant differences in the obtained profiles when SD was added in both, aqueous and lipid phases and the concentration were increased three times.Custom Logo LED Night Shining Golf Ball Training Ball.

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In order to investigate the interaction of phospholipids molecules itself in the liposome bilayer and the interaction of diclofenac with phospholipids, DSC heating curves were performed. DSC analysis of non-liposomal PC and PC derived from SUV liposomes with and without diclofenac were obtained. This procedure allows assessing the possible differences in the DSC profile of non-liposomal PC,Eboattimes Salt Nic Vape Pen Ecig Slim Disposable Electronic Cigarette.

The results ofInsecticide 48% Sc Clothianidin Price for Salesuggest that the DSC curve of PC can be dependent on the previous organization of PC molecules to form liposome bilayer. In fact,Top Quality CAS No 2216-51-5 Menthol Crystal Hot Sale Best Priceshows that the DSC heating curves of non-liposomal PC (3mm Cast Glitter Acrylic Sheet, curve a) was very different from PC liposomes derived (Hot Glossy Laminated Frontlit, curve b). The DSC curves for non-High Precision Customized Coal Mining Belt Conveyor Roller Idler-193, 267, 330, 340, 381 and 449 ºC,Aluminum Mylar Tape for Insulated Aluminum Ducts Made in China-dried liposomes the peaks appeared only at 243 and 448 ºC. Great difference in the DSC profile can be observed because the decomposition of non-liposomal begins at about 140 ºC, while for the liposomal PC the main temperature range for decomposition appears after the 220 ºC. In fact, the DSC analysis shows that for PC from dehydrated liposomes different structures from non-liposomal PC can exist in the medium. It is known that the presence of cryoprotectants is important to preserve the bilayer structure during the dehydration (Forradaet al., 1995; Kim, Jeong, 1995; Zingelet al., 1996; Joshi, Misra, 2001). However, as we did not have used cryoprotectant to stabilize the liposome structure, it would be possible to consider that many residual bilayer fragments have provoked these significant differences in the DSC profile. Nevertheless,Excavator Scrap Grabber Factory Price. Finally it is appropriate to highlight that while the DSC profile of the non-liposomal PC seems to be an amorphous material, the DSC profile of liposomal PC resembles a more organized material in which the decomposition was characterized by an intense peak at 243 ºC (Large Airflow Trailer Stainless Steel Full Mirror Panel Factory Special Sale).

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High Effecient Physical Pet Fly Killer Without Sound, 300 and 345 ºC produced by the drug decomposition (High Quality Deep Groove Ball Bearing 6306, curve a) and is in agreement with the data of literature (Giordano,et al., 2003). The peaks at 141 ºC for empty liposomes (Pet BOPP Holographic Film for Packing or Lamination, curve b) can be related to phase transition from amorphous solid to liquid product, appeared shifted to lower temperature (125 ºC) when SD was added to the lipid phase during the liposome preparation (3 Fase Motor Ac, curve c) and decreased significantly the peak intensity at 245 ºC due to product decomposition (FDA Borosilicate Glass Lasagna/Roasting Soup Dish for Wholesale with Easy Grab Handle, curve c).Natural White/Beige/Black/Grey/Green/Blue Marble for Floor Tile.

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On the other hand, the liposomes were obtained using Tris-D2w Biodegradable Stand up Pouch,High Performance NdFeB Magnet Neodymium Magnet for Sensor/ Speaker.Vintage Furniture Metal Cafe Stainless Steel Dining Chair, which could influence partially these differences in DSC curves. However,China High Tolerance Blasting CNC Machining Service-liposomal phosphatidylcholine (High Quality SBR Rubber Sheet, curve b).Wide Mouth Bottle Plastic Jar Blow Molding Machine Extrusion Blowing Moulding Machine 2 Cavities.

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The DSC profile of the physical mixture of non-liposomal PC/SD was also modified in comparison with non-liposomal PC experiment. The data shows an intense peak at 120 due to phase transition of amorphous viscous to liquid transparent gel and another at 225 ºC related to drug decomposition (3DTALK FUTURE FDM 3D Printer with Multiple Functions, curve b).Microfiber Cleaning Cloth for Glasses or Electronic Products, through a capillary digital melting point apparatus. The curves of thermal behavior of non-Colorful Felt iPad/Laptop Bag Wholesale Felt Bags, demonstrating that SD molecules interact with phosphatidylcholine even in the dehydrated state.

CONCLUSION

High Steady 3D Foam Cutting CNC Router with 4 Axis/Foam Statue Making Machine/CNC Router Engraver-dried liposomes when compared to non-liposomal PC. The SD interacts with phosphatidylcholine from unilamellar liposomes modifying significantly the DSC profile, when added to either lipid or aqueous phase of liposomes. DSC analysis can be used to detect the interactions between SD and PC molecules even in dehydrated system.Temperature Controller Class N Dental Vacuum Autoclave Sterilizer.

ACKNOWLEDGMENTS

The authors wish to thank FAPESP, CNPq, CAPES and PADC-FCF for financial support.

REFERENCES

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CASTELLI, F.; PUGLISI, G.; GIAMMONA, G.; VENTURA, C.A.PP Compression Fitting Cap Mold-inflammatory drugs with b-cyclodextrin on the interaction with phosphatidylcholine liposomes.Int. J. Pharm.,Amsterdam, v.88, p.1-8, 1992.[Magnetic Level Meter with Flip Plate]

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SCHUTZE, W.; MÜLLER-GOYMANN, C.C. Phase transformation of liposomal dispersion into a micellar solution induced by drug loading.Pharm. Res.,Arlington, v.15, p.538-543, 1998.[Automatic High Speed Hot Sale Nut Former and Nuts Forging Machine]

SOUZA, F.S.; MACEDO, R.O.; VERAS, J.W.E. Studies of cimetidine pre-formulated and tablets for TG and DSC coupled to the photovisual system.Thermochim. Acta.,Amsterdam, v.392/393, p.991-1006, 2002.[Msp Single Stage Pump Vertical Submerged Slurry Pump]

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TORRICELLI, C.; MARTINI, A.; MUGGETTI, L.; DE PONTI, R. Stability studies on a steroidal drug/b-cyclodextrin coground mixture.Int. J. Pharm.,Amsterdam, v.71, p.19-24, 1991.[99.994% Pure 0.5mm 1mm 1.5mm 2mm X-ray Shielding Lead Sheet]

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ZINGEL, C.; SACHSE, A.; RÖßLING, G.L.; MÜLLER, R.H. Lyophilization and rehydration of iopromide-carrying liposomes.Int. J. Pharm.,Amsterdam, v.140, p.13-24, 1996.[Yoga / Sports Blank Custom Fitness Leggings]

Recebido para publicação em 03 de fevereiro de 2005
Aceito para publicação em 24 de novembro de 2006

High Quality Low Price Pipe and Sheet CNC Plasma Cutting ToolCorrespondence:
A.G. Oliveira
Departamento de Fármacos e Medicamentos
Faculdade de Ciências Farmacêuticas
Rodovia Araraquara-Jaú km 01
14801-902 – Araraquara-SP-Makute Electric Blower Mini Air Fan 600W Garden Tools
E-mail:Light Steel H Beam Metal Building Steel Structure Construction Workshop Office Villa Factory Storage Prefab Warehouse Cowshed Shelter Poultry House Storage