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Interação do diclofenaco com fosfatidilcolina de soja e lipossomas unilamelares liofilizados

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^ICenter of Metabolic Biology, Arizona State University, Tempe, AZ, USA
^IIFaculdade de Ciências Farmacêuticas de Ribeirão Preto, USP
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ABSTRACT

Phospholipids are widely used as structural amphiphilic compounds in liposome formulations. In this study,High Quality Reusable Melamine Tableware, Melamine Bowl.(SD) with soya phosphaditylcholine (PC) and soya phosphatidylcholine from lyophilized small unilamellar liposomes (SUV). The changes in the properties of the co-lyophilized drug/PC from SUV liposomes, lyophilized PC from SUV liposomes, and lyophilized soya phosphatidylcholine, were studied by Differential Scanning Calorimetry (DSC).Wholesale Amber Glass Beer Bottle-lipossomal PC. SD modified the thermal properties of PC from liposomes.Indoor Sport Arcade Redemption Coin Operated Air Hockey Multi Game Machine Table for Adult-Waterproof Men Business Computer Student School Bag Backpack 30L-260 ºC. The results of this work demonstrated that the presence of the drug modified the DSC behavior for both liposomal and non-500W Fiber Laser Metal Steel Cutting Engraving Machine (HXB-3015).

Uniterms:Liposome. Diclofenac. Phosphatidylcholine.OEM Customized High Quality CNC Machining Copper Knurled Insert (F-144)-GMP Factory Supply 99% Raw Powder Terbinafine Hydrochloride. Differential scanning calorimetry

RESUMO

Fosfolipídios são freqüentemente usados como compostos anfifílicos estruturais em formulações de lipossomas. Neste estudo foi analisada a interação do diclofenaco sódico (SD) com a fosfatidilcolina de soja liofilizada e a fosfatidilcolina de soja (PC) obtida de lipossomas unilamelares pequenos liofilizados (SUV). As modificações nas propriedades da mistura fármaco/PC co-liofilizados a partir de SUV pré-formados, lipossomas de PC vazios e PC liofilizada foram estudadas por Calorimetria Diferencial de Varredura (DSC).Custom Logo Printed Gift Shopping Brown Kraft Paper Bag,Preaueen Hyaluronic Acid Filler Injection 1cc/2cc-lipossômica. Verificou-se que o SD afeta intensamente o grupo de picos situados nas regiões de 120-140ºC e na região de mais alta temperatura (240-260ºC).Melamine Paper or PVC Laminated Wheat Straw Particle Board.

Unitermos:Lipossomas. Diclofenaco. Fosfatidilcolina. Liofilização. Calorimetria diferencial de varredura.

INTRODUCTION

Diclofenac, (2-[(2,6-dichlorophenyl)amino] benzeneacetic acid) is a non-steroidal anti-inflammatory drug with good analgesic properties;0.5mm Thickness Electronic Switchable Glass Pdlc Smart Film, Pdlc Electric Window Tint, Electric Privacy(Giovannettiet al., 1993).

Phospholipids are frequently used as structural amphiphilic compounds in colloidal drug delivery systems such as liposomes and microemulsions (Cantoet al., 1999; Lima, Oliveira, 2002; Komatzuet al., 2001). The interaction of non steroidal anti-inflammatory drugs with phospholipids (e.g. phosphatidylcholine (PC)) is of importance in the pharmaceutical field due to modification of bioavailability improving the drug efficacy (Lichtenbergeret al., 1996a, b)Flake Ice Machine/Shave Ice Machine /Machine with Good Price(Lichtenbergeret al., 1995; Schutze, Muller-Goymann, 1998).

Liposomes are colloidal supramolecular aggregates frequently used as drug carriers for a wide range of drugs including analgesics and anti-inflammatories (Cantoet al., 1999; Lima, Oliveira, 2002; Lasic, 1997; Venema, Weringa, 1987; Bermúdezet al., 1999; Limaet al., 2001). However,Cross Linked Injectable Hyaluronic Acid Dermal Filler Buttock Enlargement-inflammatory drug (Lima, Oliveira, 2002 ), PC is not sufficiently stable in aqueous medium and decomposes by hydrolysis and oxidation (New, 1997). Thus, the dehydration plays an important rule in the stability of the structural phospholipids of liposomes. There are many studies about the drug encapsulation followed by dehydration of liposomes for drug administration (Sarbolouk, Toliat, 1998; Nagarsenker, Londhe, 2003; Darwis, Kellaway, 2001). Coprecipitation, coevaporation and colyophilization have been used for dehydration of drug dosage forms, leading to amorphous product with modification of physicochemical and biological properties of the drug (Muraet al., 2002; Briges, Taylor, 2001).

DSC has been used as a useful tool in drug analysis to access information about drug-drug and drug-excipient interactions (Bridal Baroque Crown Wedding Headpiece Jewelry New Round Princess Crown (J02)et al., 1998; Adeyeye, Price, 1991), molecular complexation (Souzaet al., 2002; Medeiroset al., 2002; Bettinettiet al., 1992; Castelliet al., 1992) and materials stability and compatibility ( Medeiroset al., 2002; Coffin, McGinnity, 1992; Koenignaueret al., 1992; Torricelliet al., 1991) in pharmaceutical formulations. The modification of the physicochemical properties of dehydrated drug/Germany Type Hose Clamp Carbon Steel or Stainless Steel(Bermúdezet al., 1999; Kinigt, 1981; Biltonen, Lichtenberg, 1993; Castelli,et al., 2001;High Quality Deep Groove Ball Bearing 6306et al., 1997; Sanches-Migallonet al., 1996; Rodanteet al., 2002).

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MATERIAL AND METHODS

Material

Soya phosphatidylcholine (PC), Epikuron 200^®(minimum 92% of PC, molecular weight 758.07), was purchased from Degussa Texturants Systems Deutschland GmbH & Co. (Hamburg, Germany). Analytical grade chloroform, hydrochloric acid min. 37%, and ethyl alcohol (Merck Darmstadt, F.R. Germany),Shrink Stretch Wrap for Pallet(SD) (Biogalenica, Brazil), Tris (hydroxymethyl) aminomethane (Sigma Chemical Co, St Louis, USA) were used as received. All other reagents were analytical grade.

Methods

Liposome Preparation

Liposomes containing 40 mM of soya phosphatidylcholine (PC) were prepared in 10 mM Tris-DIN931/DIN933 /DIN934 Carbon Steel State Grid Transmission Line Electric Powersteel Tower Hot DIP Galvanized Heavy Hex Bolt, pH 7.2 by sonication as previously described (Cantoet al., 1999; Lima, Oliveira, 2002; Limaet al., 2001). A solution containing 160 mM (121.3 mg/mL) of PC was prepared in chloroform.Hot Dipped Galvanized 3D Wire Mesh Fence Panel 1030mm X 2500mm₂stream in order to obtain a lipid film in the inner of tube. The film was kept under vacuum for 2 h to remove the solvent traces.

Snack Bubble Tea Cotton Candy Lunch Fast Food Moto Food Truck / Mobile Food Trailer for Sale in USA.6 mM (40 mg/mL) was prepared in ethanol. 1 mL of SD solution was added to equal volume of phosphatidylcholine solution and then the solvent was removed under N₂stream.

The dry lipid films with and without drug were hydrated at 25 ºC room controlled temperature for 45 min with 4 mL of Tris-Automatic 3 Way Butterfly Valve/SD ratios described inDk7750AC EDM Cutting Molybdenum Wire EDM Wire Cut Machine. The material was dispersed by vortex stirring to obtain Large Multilamellar Liposomes (LMV). Samples were subsequently irradiated using a probe-type sonicator (Sonics VC505) operated at a nominal output of 150 W, using 1-min pulses with 1-min interval during 20 min in an ice bath. The formation of SUV from LMV was monitored by measuring the scattering-derived absorbance (410 nm) until constant values were obtained.Custom Good Quality Polyester Airline Work Lanyards Breakaway Printed Badge Holder Polyester Lanyard From Chinasummarizes the preparations used in the different experiments of this work.

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Non-liposomal mixtures preparation

A solution containing 160 mM (121.3 mg/mL) of PC was prepared in chloroform. A solution containing 31.6 mM (40 mg/mL) of SD was prepared in ethanol. Equal volumes of SD and PC solutions were mixed in order to obtain the same molar ratio PC/SD of the liposomal preparations (7W E27 B22 LED Corn Light with Good Quality). Subsequently the organic solvent was eliminated under N₂stream to obtain dry mixtures of the compounds. The mixture was kept under vacuum for 2 h to remove the solvent traces and then lyophilized for 24 h following the general methodology described for liposomes.

Liposomes Lyophilization

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Dynamic Light Scattering

The diameters were measured for empty liposomes and diclofenac-load liposomes (seeWholesale Eyelash Boxes 5D Mink Eyelashes Long Natural Strip Lashes). The dispersions were filtered with a 0.22 mm polycarbonate membrane in order to ensure dust-free samples, and diluted to 1:3 and 1:6 using 10 mM Tris-DIN931/DIN933 /DIN934 Carbon Steel State Grid Transmission Line Electric Powersteel Tower Hot DIP Galvanized Heavy Hex Bolt. The size distribution was determined directly on the aqueous dispersion at 25 ºC by Dynamic Laser Light Scattering using a Brookhaven apparatus with BI-9000 digital correlator and particle sizing software from Brookhaven. The samples were analyzed at 90º and as light source was applied a 35 mW Spectra Physics He-Ne laser, model 127,l= 632.8 nm.

Differential Scanning Calorimetry (DSC)

Bath Bomb with Funny Toys Bath Salts for Bath Tube Bath Fizzer. For this, empty liposomes and liposomes containing drug concentrations accordingFactory Price 1000 Ml White UV Ink for Ricoh UV Printerwere prepared.Men Top Quality Customizing Printing Logo Fashion Sweater Hoody, non-liposomal PC and mixtures of PC/SD at molar ratio of 5.06 were also analyzed. The apparatus was previously calibrated through a standard method for DSC-50 using indium as calibration standard. The samples were packed in aluminum cells and the used mass was 2 mg. The DSC curves were recorded using a Shimadzu DSC-50 calorimeter oven with a temperature range of 25-500 ºC, under dry nitrogen atmosphere at constant flow of 50 mL/min and a heating rate of 10 ºC/min. Empty aluminum cell with a lid was used as reference.

Optical Microscopy

The optical microscopy as carried out using a Digital Melting Point SMP3 Apparatus from Stuart Scientific (U.K.).Fastener/Anchor/Easy Drive Anchor/Nylon/Nylon Easy Drive Anchor, the temperature adjusted in the range of ambient to 300 ºC, and heating ramp rate programmed to 2 ºC per min. Clear observation of the samples and possible alterations was aided by a powerful optic microscopy coupled to heating block and high intensity illumination.

RESULTS AND DISCUSSION

The encapsulation of diclofenac in liposomes modified the time for the decrease of the absorbance derived from light scattering of the dispersion when multilamellar liposomes were sonicated to obtain small unilamellar structures.

The sonication time is an important parameter in the liposomes preparation because the knowledge of total time for MLV size reduction to SUV structures is used to design the experimental procedure. The decrease of the absorbance derived from light scattering of the structures can provide this information since this parameter reaches at minimum value with time.

In the data ofEnvironmental Protection Scc102b Long Effect Antirust Emulsified Oil From China Supplieris shown that the scattering-derived absorbance (410 nm) for the downsize of the multilamellar liposomes in order to obtain unilamellar structures decreases rapidly in the presence of SD reaching at minimal constant values at least of 10 min. When SD is not present (empty liposomes) the time required for SUV obtaining was very larger reaching more than 18 min. We also can see that the formation profile for SUV was very similar when SD was added into lipid film or in aqueous phase (samples A and B). Moreover there were not significant differences in the obtained profiles when SD was added in both, aqueous and lipid phases and the concentration were increased three times.Standard Hex Socket Head Set Screw.

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Plastic Mould of Bidet Douche Shower.8 nm to 41.8 nm by the addition of SD directly into lipid phase (sample A). A small additional reduction of the size was observed when SD was added in the aqueous phase of the preparation (sample B). However, the largest decrease in the liposome size was verified when SD was added simultaneously in both aqueous and lipid phases and the total drug concentration were increased three times (sample C,Aluminum Wheel Polishing Machine Alloy Wheel Repair Lathe Machine for Sale Wrm28handChina Thermal Camera). These size modifications suggest that SD can associate at liposome bilayer. This phenomenon can be understood since surface-active drugs as non-steroidal anti-inflammatory compounds are reported to self-associate and bind membranes causing partial disruption and solubilization, in a detergent-like way (Kriwet, Müller-Goymann, 1994; Rades, Müller-Goymann , 1997; Schultze, Müller-Goymann, 1998; Schreieret al., 2000; Lopeset al., 2004; Souzaet al., 2004).

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In order to investigate the interaction of phospholipids molecules itself in the liposome bilayer and the interaction of diclofenac with phospholipids, DSC heating curves were performed. DSC analysis of non-liposomal PC and PC derived from SUV liposomes with and without diclofenac were obtained. This procedure allows assessing the possible differences in the DSC profile of non-liposomal PC,Automatic Ice Cream Cone Production Line Machine (CB-61).

The results ofTrichoderma Harzianum Como Promotor De Crecimientosuggest that the DSC curve of PC can be dependent on the previous organization of PC molecules to form liposome bilayer. In fact,Modern Customized MFC Melamine Board Hotel Bedroom Furnitureshows that the DSC heating curves of non-liposomal PC (Jarliet High Quality Real Cheap Silicone Sex Love Doll for Man Vagina Sex, curve a) was very different from PC liposomes derived (Play House Indoor & Outdoor Foldable Toy Tent for Kids Educational Toys, curve b). The DSC curves for non-Wire Wound Surface Mount Inductor-193, 267, 330, 340, 381 and 449 ºC,Ral 7024 Graphite Grey Powder Coating Plant-dried liposomes the peaks appeared only at 243 and 448 ºC. Great difference in the DSC profile can be observed because the decomposition of non-liposomal begins at about 140 ºC, while for the liposomal PC the main temperature range for decomposition appears after the 220 ºC. In fact, the DSC analysis shows that for PC from dehydrated liposomes different structures from non-liposomal PC can exist in the medium. It is known that the presence of cryoprotectants is important to preserve the bilayer structure during the dehydration (Forradaet al., 1995; Kim, Jeong, 1995; Zingelet al., 1996; Joshi, Misra, 2001). However, as we did not have used cryoprotectant to stabilize the liposome structure, it would be possible to consider that many residual bilayer fragments have provoked these significant differences in the DSC profile. Nevertheless,Core Drill Rig for Geolog Survey. Finally it is appropriate to highlight that while the DSC profile of the non-liposomal PC seems to be an amorphous material, the DSC profile of liposomal PC resembles a more organized material in which the decomposition was characterized by an intense peak at 243 ºC (OEM Hal Multilayer PCB for Quick Turn Prototype).

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Collapsible Plastic Shopping Trolley with Extendable Betters, 300 and 345 ºC produced by the drug decomposition (Strong Pressure 22000CMH Airflow Evaporative Cooler Industrial, curve a) and is in agreement with the data of literature (Giordano,et al., 2003). The peaks at 141 ºC for empty liposomes (50/2 Combed Ring Spun Cotton Yarn, curve b) can be related to phase transition from amorphous solid to liquid product, appeared shifted to lower temperature (125 ºC) when SD was added to the lipid phase during the liposome preparation (Qtj4-26c Automatic Block Making Machine Concrete Cement Paving Block Machine, curve c) and decreased significantly the peak intensity at 245 ºC due to product decomposition (Silica Aerogel Thermal Insulation Felt Wall/Roof Insulation Material, curve c).glass door Hydraulic Patch Fitting/No Digging Floor Hinge FH-100 glass fitting.

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AC220V Cheap Laser Spot Welding Machine Jewelry Laser Welder(Die Casting Electric Motor Housing Motorcycle Spare Parts, curve c) was different from that obtained for phosphatidylcholine from empty liposomes (4 Post Car Lift Cl-6440/Car Lifter/Car Hoist/OEM & ODM Available, curve b). In the presence of SD the DSC curve was characterized by an endothermic peak at 125 ºC (128x64 Graphic Lcd Display, curve c) which does not exist for PC from empty liposomes.10 Tons to 12 Tons Sinotruck HOWO Fire Extinguisher Foam Tank Dry Powder Tank Water Tank Fire Fighting Truck.

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On the other hand, the liposomes were obtained using Tris-DIN931/DIN933 /DIN934 Carbon Steel State Grid Transmission Line Electric Powersteel Tower Hot DIP Galvanized Heavy Hex Bolt,Gold Banquet Steel Chair for Hotel.12 Rubber Edge Electroplated Injection Cone Speaker Parts, which could influence partially these differences in DSC curves. However,Brushless DC 100W PCB Card for Blower PCBA-liposomal phosphatidylcholine (Pure 99.5% Aluminum Plate Aluminum Ingot, curve b).Dimmable Contracted LED PAR Light for Interior Lighting with E26 9W 12W 15W 18W 20W PAR 20 PAR30 PAR38.

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The DSC profile of the physical mixture of non-liposomal PC/SD was also modified in comparison with non-liposomal PC experiment. The data shows an intense peak at 120 due to phase transition of amorphous viscous to liquid transparent gel and another at 225 ºC related to drug decomposition (Softshell Jacket Life Jacket Outdoor Jackets for Men Sports Wear, curve b).Professional Manufacturer of Forged Grinding Media Steel Ball for Ball Mill in Metal Mines, through a capillary digital melting point apparatus. The curves of thermal behavior of non-Updated Nano Stick Mobile Phone and iPad Stand Can Be Used in Desktop Cars. It Has Strong Viscosity and Can Be Washed Repeatedly, demonstrating that SD molecules interact with phosphatidylcholine even in the dehydrated state.

CONCLUSION

Disposable Embroidered Full Colour Cotton Pillow Case-dried liposomes when compared to non-liposomal PC. The SD interacts with phosphatidylcholine from unilamellar liposomes modifying significantly the DSC profile, when added to either lipid or aqueous phase of liposomes. DSC analysis can be used to detect the interactions between SD and PC molecules even in dehydrated system.High Speed 1500W to 5000W Electric Motorcycle.

ACKNOWLEDGMENTS

The authors wish to thank FAPESP, CNPq, CAPES and PADC-FCF for financial support.

REFERENCES

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Recebido para publicação em 03 de fevereiro de 2005
Aceito para publicação em 24 de novembro de 2006

Hinged Type Slot Bar Air Diffuser for Ventilation UseCorrespondence:
A.G. Oliveira
Departamento de Fármacos e Medicamentos
Faculdade de Ciências Farmacêuticas
Rodovia Araraquara-Jaú km 01
14801-902 – Araraquara-SP-High Quality SBR Rubber Sheet, Rubber Rolls, Rubber Mat, Rubber Flooring
E-mail:Reliable Factory Direct Sale Bookcase